Effects of Insulin and Activity on Pentose Transport Into Muscle

Abstract

The effects of insulin and muscular activity on the transport across the cell membrane of muscle of pentoses having the same steric configuration about carbon atoms 1, 2 and 3 as d-glucose has, were found to be additive in the nephrectomized cat. The degree of intracellular penetration of l-arabinose into muscle was found to be related to the extent of activity. The results suggest that the effect of muscular activity on pentose penetration is not due to a humoral agent. They also suggest that insulin and muscular activity exert their effects by different mechanisms.