Gastric Contractions in the Rat

Author:

Morrison Seoras D.1,Lin Hsiang Ju1,Eckel Helen E.1,Van Itallie Theodore B.1,Mayer Jean1

Affiliation:

1. From the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Abstract

A method is described for continuous recording of gastric concentrations in the normal rat. Fasting concentrations normally show a cyclical behavior with a period of 15–20 minutes. These concentrations are inhibited by instillation of many substances into the stomach via a permanent gastric fistula, the duration of the inhibition varying with volume and concentration. Neither glucose nor insulin given i.v. affects the fasting contractions; however, 0.1 mg of intravenous glucagon invariably produces complete inhibition of contractions for 4–7 minutes.

Publisher

American Physiological Society

Subject

Physiology (medical)

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