Effect of Estrone on Some Criteria of Thyroid Function

Abstract

The effects of estrogen upon thyroidal I131 uptake, hormone discharge, total iodine content and distribution of radioiodine among the iodinated amino acids of the thyroid gland have been investigated in orchiectomized rats. Acute administration of estrone increased significantly the 24-hour I131 uptake and augmented thyroidal weight at the higher of the two levels employed. It had no effect upon the serum PBI, the I127 content of the thyroid or the iodinated amino acid pattern. I131 discharge from the thyroid was slowed significantly by estrone, both on a stock diet and when propylthiouracil was used to block I131 reaccumulation.