Effect of Varying the Hematocrit Ratio on the Susceptibility to Hemorrhagic Shock

Author:

Crowell Jack W.1,Bounds Sara H.1,Johnson W. W.1

Affiliation:

1. From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi

Abstract

By the use of a) acetyl phenylhydrazine, b) hemorrhage, c) transfusion, and d) natural variation, 67 dogs with hematocrit ratios varying from 12 to 56 were obtained. These dogs were subjected to hemorrhagic shock by lowering their arterial blood pressure to 30 mm Hg, and the time lapse between the initial production of hypotension and the beginning deterioration of the animal determined. This time lapse is a measure of the resistance of the animal to the development of irreversible shock. A graph of initial hematocrit versus the time required for the development of irreversible shock shows that an increase in the hematocrit ratio from 12 to 35 increases the resistance of the animals by a factor of approximately 5; however, increasing the hematocrit ratio above 35 decreases the resistance of the animal to the development of irreversible shock.

Publisher

American Physiological Society

Subject

Physiology (medical)

Cited by 43 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pathophysiology of hemorrhagic shock;Journal of Veterinary Emergency and Critical Care;2022-01

2. Controversies related to red blood cell transfusion in critically ill patients;Journal of Veterinary Emergency and Critical Care;2010-04

3. Rat Strains Bred for Low and High Aerobic Running Capacity Do Not Differ in Their Survival Time to Hemorrhage;Experimental Biology and Medicine;2009-12

4. Irreversible Shock Is Not Irreversible: A New Model of Massive Hemorrhage and Resuscitation;The Journal of Trauma: Injury, Infection, and Critical Care;2001-05

5. Y a-t-il des limites à l'hémodilution ?;Annales Françaises d'Anesthésie et de Réanimation;1995-01

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