Effect of Liver on Lipolysis by Normal and Postheparin Sera in the Rat

Abstract

Lipolysis by sera heparinized in vivo and by normal sera was studied after perfusion through isolated rat liver. The rate of clearing of an oil emulsion by serum containing clearing factor was decreased after perfusion through the liver. The extent of clearing was not always affected. Clearing factor activity was lessened by incubation with heparinase (prepared from rabbit livers). Normal rat serum exhibited consistent lipolytic activity following perfusion through the isolated liver. This activity was not due to clearing factor.