Affiliation:
1. From the Department of Neurophysiology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.
Abstract
The effects of autonomic agents on anterior pituitary-adrenal cortical axis in dogs were studied. 17-hydroxycorticosteroids (17-OH-CS), determined by Nelson-Samuels method, and eosinophils, by Randolph procedure, were measured in normal animals and following saline, ACTH, l-epinephrine, l-norepinephrine and physostigmine. Concentrations of 17-OH-CS three to four times the initial plasma levels were achieved by ACTH (0.4–4.0 mg/kg). Epinephrine (0.12 mg/kg) caused approximately twofold increases. Norepinephrine (0.017 mg/kg) and physostigmine (0.05 mg/kg) had no effect on 17-OH-CS concentration. Marked eosinopenia resulted from ACTH, epinephrine and physostigmine.
Publisher
American Physiological Society
Cited by
21 articles.
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