Biosynthesis of Fatty Acids in Liver and Intestine of Intact Normal, Fasted and X-Irradiated Rats

Abstract

A 72-hour fasting period affects intestinal incorporation of C14-acetate into fatty acids to a smaller extent that it does hepatic incorporation. Glycogen concentration and hepatic incorporation of acetate into fatty acids increases in irradiated, fasted rats (750 r total-body x-irradiation) compared to fasted controls. Intestinal incorporation of C14-acetate into fatty acids decreases in the irradiated rat. A direct relationship between the amount of liver glycogen present and the amount of incorporation of C14 into fatty acids was not observed at these levels of hepatic glycogen and lipogenesis.