Inhibition of inotropic effect of hyperosmotic mannitol by lactate in vitro

Author:

Crie JS,Wildenthal K,Adcock R,Templeton G,Willerson JT

Abstract

Isolated, isometrically contracting cat papillary muscles were used to evaluate the inotropic interactions of lactic acidosis, hypercarbic acidosis, and lactate ion with hypertonic mannitol. These studies have documented that both lactic acidosis (pH less than 7.0) and lactate ion at a normal pH inhibit the inotropic effect of hyperosmotic mannitol in vitro. In contrast, hypercarbic acidosis does not prevent the inotropic effect of mannitol. Inhibition by lactic acid of mannitol's effects on contractility persists in the presence of beta-receptor blockade. The results suggest that inhibition by severe lactic acidosis of the direct inotropic effect of hyperosmolality in isolated cardiac muscle is mediated by lactate ion rather than acidosis per se.

Publisher

American Physiological Society

Subject

Physiology (medical)

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Acidosis and Contractility of Heart Muscle;Ciba Foundation Symposium 87 - Metabolic Acidosis;2008-05-30

2. James Thornton Willerson, MD: A Conversation With the Editor;The American Journal of Cardiology;1997-02

3. Lactic acidosis: effect of treatment on intracellular pH and energetics in living rat heart;American Journal of Physiology-Heart and Circulatory Physiology;1992-05-01

4. The oxygen supply dependency phenomenon is associated with increased blood lactate levels;Journal of Critical Care;1991-09

5. Sodium Bicarbonate in the Treatment of Subtypes of Acute Lactic Acidosis;Anesthesiology;1990-06-01

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