Anti-inflammatory activity of some water-soluble bioflavonoids

Abstract

The water-soluble citrus bioflavonoid mixture contained in the preparation C.V.P., without added vitamin C, is capable of inhibiting the increased capillary permeability referable in turn to an inflammatory exudate, irrespective of the pH of that exudate. The suppressing effect of these water-soluble bioflavonoids can be demonstrated in concentrations of 5 or 10 mg/0.25 ml of exudative material. They likewise inhibit the effect of leukotaxine that has been extracted from alkaline exudates. In this way they repress not only increased permeability of capillaries, but also the local emigration of leucocytes. Finally this water-soluble bioflavonoid mixture appears to behave as an anti-inflammatory agent over a larger pH range of exudates than either cortisone or corticotropin, (ACTH). Cortisone represses permeability increase and leucocytic migration of alkaline exudate. ACTH suppresses the activity of exudin in its ability to increase local capillary permeability induced by acid exudates. This bioflavonoid mixture is capable of inhibiting in this regard both alkaline and acid exudates. The possible potentials of C.V.P. are pointed out.