Oxygen transport in hemorrhagic shock as a function of the hematocrit ratio

Author:

Crowell Jack W.1,Ford Robert G.1,Lewis Virginia M.1

Affiliation:

1. Department of Physiology and Biophysics, University Medical Center, Jackson, Mississippi

Abstract

The oxygen consumption, arterial and venous oxygen concentration, and the arterial blood pH were measured, and the cardiac output, peripheral resistance and maximum oxygen transport capacity determined in 75 dogs with different hematocrit ratios in which the blood pressure had been maintained at 30 mm Hg for 15 minutes. The O2 consumption increased as the hematocrit ratio increased until the hematocrit ratio reached 42. However, an increase in the hematocrit ratio above 42 caused a decrease in O2 consumption. This optimal hematocrit ratio occurs because of the dual role of the hematocrit ratio in determining O2 content of blood and blood viscosity. A curve obtained by multiplying cardiac output times arterial O2 showed that when the hematocrit ratio is 42 the O2 transport is maximal. The oxygen consumed by the animal was determined by the oxygen available. Arterial blood pH was highest in those dogs with the greatest oxygen consumption, but the pH was below limits compatible with life in the anemic animals. Total peripheral resistance increased greatly as the hematocrit ratio increased. Analysis of the data showed that the rate of maximum resistance to hemorrhagic shock coincides with the hematocrit ratio range of maximum O2 transport. Also, the rate of development of an oxygen debt determines how long the animals can remain hypotensive without developing irreversible shock and indicates that, regardless of the hematocrit ratio, a fixed oxygen deficit must occur before irreversible shock develops.

Publisher

American Physiological Society

Subject

Physiology (medical)

Cited by 100 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3