Affiliation:
1. Department of Pharmacology, Harvard Medical School, and Department of Oral Pathology, Harvard School of Dental Medicine, Boston, Massachusetts
Abstract
The media from resorbing mouse calvaria in tissue culture were analyzed for citric acid, calcium, phosphorus, lactic acid, protein, sodium, glucosamine and mucoprotein "tyrosine." Paralleling the resorption of bone seen morphologically, increases in citric acid, calcium and phosphorus were observed. With the exception of lactic acid no changes in other constituents were noted. The cumulative increase in citric acid was 8–19 times greater than the total citric acid content of the original calvaria. It is concluded that the resorbing bone is capable of producing citric acid metabolically, a concept which has until now lacked direct evidence.
Publisher
American Physiological Society
Cited by
44 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献