Mitochondrial regulation of tissue respiration

Author:

Miller A. T.1,Conoly D. M.1,Gabriel M.1,Handy M. S.1

Affiliation:

1. Department of Physiology, University of North Carolina Medical School, Chapel Hill, North Carolina

Abstract

Mitochondrial and nuclear counts and homogenate and washed mitochondrial qO2 determinations were made on kidney cortex, liver and brain of albino rats. Homogenate qO2 was inversely related to mitochondrial count in the three tissues, but directly related to cellularity and to O2 uptake per mitochondrion. It is shown that the former is a spurious and the latter a real correlation. It is concluded that the characteristic differences in the qO2 of these three tissues are due largely to specific differences in the oxidative metabolism of their respective mitochondria and not to differences in the mitochondrial count per unit weight of tissue.

Publisher

American Physiological Society

Subject

Physiology (medical)

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. OXYGENATION OF THE TISSUE CELL;Annals of the New York Academy of Sciences;2007-03-14

2. Increased oxidative metabolism in the fetal and newborn lamb heart;American Journal of Physiology-Legacy Content;1972-06-01

3. Protein Synthesis;Metabolic Turnover in the Nervous System;1971

4. Properties of mitochondria from hearts of cattle acclimatized to high altitude;Respiration Physiology;1970-01

5. The ischemic zone surrounding acute myocardial infarction. Its morphology as detected by dehydrogenase staining;American Heart Journal;1968-11

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