Effect of d-l-ethionine on electrolyte secretion of the dog pancreas

Abstract

The secretion of fluid and electrolytes, as well as amylase, was studied in response to secretin and pancreozymin stimulation in unanesthetized dogs fitted with a Thomas-type duodenal fistula by inserting a cannula directly into the main pancreatic duct before and during a 3-week period of ethionine administration. In addition to the well-established destructive effect of d-l-ethionine on the acinar cell and its secretion of enzymes, changes occurred in the secretion of HCO3 and H2O in response to secretin. During the early phase of ethionine intoxication (weeks 1–2) HCO3 concentration fell despite preservation of the volume rate of flow. During the second and third weeks, HCO3 concentration was preserved despite marked reduction in volume rate of flow. It is suggested that these findings may be correlated with changes in ductular as well as acinar cells. Na and K concentration, juice osmolality, and the reciprocal Cl-HCO3 relationship were unaltered.