Movement of fluid, albumin, and globulins with overtransfusion and hemorrhage

Author:

Deavers S.1,Smith E. L.1,Huggins R. A.1

Affiliation:

1. Departments of Physiology, Baylor University College of Medicine and the University of Texas Dental Branch, Houston, Texas

Abstract

Two groups of 18 morphine-pentobarbitalized dogs were used for the experiments. Determinations of plasma volume and protein concentration were made before and after the experimental procedures. The first group was bled to a mean arterial pressure of 35 mm Hg. During an average bleeding time of 74 min in which the dogs bled 48% of their circulating plasma and 47% of their total protein, 29% of the plasma and 14% of the protein removed has been replaced from extravascular sources. Those dogs that bled for the longest time gained the greatest amount of fluid and protein. Globulins comprised 74% of the protein mobilized. The second group of dogs was overtransfused with a mean volume of 85 ml/kg of whole blood. Thirty minutes after the transfusion, 20 ml/kg of plasma and 0.53 g/kg of protein escaped from the vascular system. No correlation was found between the rate of infusion and the rate of fluid and protein loss. Seventy per cent of the total protein leaving the circulation was albumin.

Publisher

American Physiological Society

Subject

Physiology (medical)

Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Continuous blood densitometry: fluid shifts after graded hemorrhage in animals;American Journal of Physiology-Heart and Circulatory Physiology;1986-03-01

2. The circulatory effects of acute hypervolemia and hemodilution in conscious rabbits.;Circulation Research;1981-06

3. INCREASED CAPILLARY PERMEABILITY TO 125I-LABELED ALBUMIN DURING EXPERIMENTAL HEMORRHAGIC SHOCK*,†;Transactions of the New York Academy of Sciences;1973-03

4. Plasma calcium concentration changes in hemorrhagic shock;American Journal of Physiology-Legacy Content;1971-04-01

5. ANOMALOUS BEHAVIOUR OF BLOOD VOLUME FOLLOWING ACUTE SEVERE HAEMORRHAGE;Australian Journal of Experimental Biology and Medical Science;1970-12

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