Hemodynamic effects of eledoisin, kallidin II, and bradykinin in unanesthetized dogs

Abstract

The hemodynamic effects of bradykinin, kallidin II, and eledoisin were compared in unrestrained dogs. Bradykinin and kallidin II were found to be short-acting depressors that increased cardiac output and decreased peripheral resistance. The effects of eledoisin were similar with 10 to 20 times less dosage. With increasing dosage, cardiac output was greatly reduced rather than raised and reduction of arterial pressure was prolonged. Eledoisin given intravenously lowered the blood pressure elevated by angiotensin. Its depressor effects were potentiated by tetraethylammonium chloride.