Renal tubular secretion of o-acetylaminohippurate

Abstract

Renal tubular transport of o-acetylaminohippurate (OAAH) was investigated because of previous reports that it differed from other hippurates by not undergoing tubular secretion. However, tubular secretion was readily demonstrable in nine clearance experiments in dogs. Secretion was decreased by succinate, 2,4 DNP, probenecid, hippurate, and Diodrast, substances all known to inhibit secretion of other hippurates. In vivo deacetylation was demonstrated. In slice system of rabbit kidney cortex, accumulation was also shown, but degree of uptake was complicated by deacetylation to OAH. Meta and para isomers did not undergo deacetylation. Both in clearance studies and in kidney slices, the transport of OAAH is qualitatively similar to other hippurates.