Active transport of iodide by choroid plexus of the rabbit in vitro

Abstract

When incubated in vitro in a saline medium containing I131 as iodide, the chloride plexus accumulates this ion. The process by which iodide is transported resembles other extrathyroidal iodide concentrating mechanisms in that it is inhibited by a number of metabolic poisons and by perchlorate, thiocyanate, fluoroborate, fluorosulfonate, difluorophosphate, and nitrate. It depends for optimal function on the presence of oxygen, potassium, and calcium in the external medium, and is able to proceed at a reduced rate in the absence of glucose from the medium. Under optimal conditions approximately 5 x 10–11 moles 1–/mg dry weight/min are accumulated.