Ionic effect on intestinal transport of glucose in the rat

Abstract

A loop of upper jejunum of anesthetized rats was perfused in situ with glucose (500 mg/l.) dissolved in either isosmotic Na2SO4, Li2SO4, K2SO4 or MgSO4. Rapid glucose absorption takes place from the Na2SO4 solution, whereas the glucose transport is inhibited if Na is replaced. The rate of inhibition varied: 91% with Li, 86% with K and 75% with Mg. The inhibition is reversible by the subsequent perfusion of the same gut with Na2SO4.