Affiliation:
1. Department of Physiology, University of Arizona, Tucson, Arizona
2. Department Biomedical Engineering, University of Arizona, Tucson, Arizona
Abstract
Dopamine by bright light conditions allows retinal neurons to reduce sensitivity to adapt to bright light conditions. It is not clear how and why dopamine receptors modulate retinal ganglion cell signaling. We found that both D1 and D4 dopamine receptors in photoreceptors and inner retinal neurons contribute significantly to the reduction in sensitivity of ganglion cells with light adaptation. However, light adaptation also requires dopamine-independent mechanisms that could reflect inherent sensitivity changes in photoreceptors.
Funder
HHS | NIH | National Eye Institute
HHS | NIH | National Heart, Lung, and Blood Institute
International Retinal Research Foundation
National Science Foundation
U.S. Department of Veterans Affairs
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Cited by
6 articles.
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