Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits

Abstract

Movements of patients with Parkinson’s disease are often less impaired when guided by external stimuli than when generated based on internal goals. Whether this effect is due to distinct processing in the basal ganglia (BG) or due to compensation from other motor pathways is an open question with therapeutic implications. We recorded BG output in behaving parkinsonian mice and found that BG activity during movement preparation was consistent with the differences between these forms of movement.