Mechanisms of severe acute intermittent hypoxia-induced phrenic long-term facilitation

Author:

Nichols Nicole L.1ORCID,Mitchell Gordon S.1

Affiliation:

1. Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin

Abstract

Distinct mechanisms give rise to pLTF induced by moderate and severe AIH. We demonstrate that, unlike moderate AIH, severe AIH-induced pLTF requires EPAC and PI3K/Akt and is marginally constrained by NADPH oxidase activity. Surprisingly, sAIH-induced pLTF requires MEK/ERK activity similar to moderate AIH-induced pLTF and is reduced by PKA inhibition. We suggest sAIH-induced pLTF arises from complex interactions between dominant mechanisms characteristic of moderate versus severe AIH-induced pLTF.

Funder

Francis Family Foundation

HHS | NIH | Office of Extramural Research, National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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