Loneliness is linked to specific subregional alterations in hippocampus-default network covariation

Abstract

The hippocampus and default network have been implicated in rich social interaction. Yet, these allocortical and neocortical neural systems have been interrogated in mostly separate literatures. Here, we conjointly investigate the hippocampus and default network at a subregion level, by capitalizing structural brain scans from ∼40,000 participants. We thus reveal unique insights on the nature of the “lonely brain” by estimating the regimes of covariation between the hippocampus and default network at population scale.