Neonatal microglia transplantation at early stage but not late stage after traumatic brain injury shows protective effects in mice-Reference-Cited by-同舟云学术

Neonatal microglia transplantation at early stage but not late stage after traumatic brain injury shows protective effects in mice

Published:2024-04-01 Issue:4 Volume:131 Page:598-606
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Chen Maosong¹,Wang Hongcai¹,Chen Pandi¹,Zhu Guangyao¹,Li Shiwei¹,Li Zengpan²,Liu Xuelan²,Ye Gengfan¹,Chen Wei¹³^ORCID

Affiliation:

1. Department of Neurosurgery, the Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China

2. Department of Emergency and Trauma Center, the Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China

3. Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Pudong New Area, Shanghai, China

Abstract

The study demonstrated that neonatal microglia transplantation within 1 h significantly inhibited the pathogenesis of traumatic brain injury (TBI) in mouse models through inhibition of M1 polarization and promotion of M2 polarization.

Funder

the Project of NINGBO Leading Medical & Health Discipline

Ningbo Municipal Bureau of Science and Technology

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00006.2024

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