The paired-pulse TMS paradigm of short intracortical inhibition is mediated by a reduction of repetitive motor neuron discharges

Author:

Batzianouli Eleni T.12ORCID,Caranzano Leonardo1ORCID,Nguepnjo Nguissi Nathalie A.1,Miaz Baptiste1,Herrmann François R.3,Benninger David H.1ORCID

Affiliation:

1. Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

2. Lemanic Neuroscience Doctoral School, Faculté de Biologie et de Médecine, Université de Lausanne, Lausanne, Switzerland

3. Division of Geriatrics and rehabilitation, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva, Geneva, Switzerland

Abstract

Significant reduction of repetitive motor neuron discharges (repMNDs) in short-interval intracortical inhibition (SICI) may result from the suppression of later I-waves and mediate the inhibition of motor-evoked potential (MEP). There is no change in the number of repMNDs in intracortical facilitation (ICF). There was a significant variability in SICI and ICF in healthy subjects.

Publisher

American Physiological Society

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