Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice-Reference-Cited by-同舟云学术

Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice

Published:2022-01-01 Issue:1 Volume:322 Page:E1-E9
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Fan Xiaojing¹²³^ORCID,Chen Defu⁴,Wang Ying²,Tan Yizhou²,Zhao Hongyou⁴,Zeng Jing²,Li Yunqi²,Guo Xianghuan¹²,Qiu Haixia²,Gu Ying²⁵⁴^ORCID

Affiliation:

1. Medical School of Chinese People’s Liberation Army, Beijing, China

2. Department of Laser Medicine, The First Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, China

3. Department of Endocrinology, The Fifth Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, China

4. Institute of Engineering Medicine, Beijing Institute of Technology, Beijing, China

5. Precision Laser Medical Diagnosis and Treatment Innovation Unit, Chinese Academy of Medical Sciences, Beijing, China

Abstract

Glucose and lipid homeostasis is altered by the CD cycles in a light-intensity-dependent manner. Lower-intensity light reverses the negative metabolic effects of the CD cycles, especially under HFD feeding. The interaction of light intensity and light cycle on metabolism is independent of energy intake and eating pattern. Glucose metabolic disorders caused by rotating light cycles occur along with compensatory β-cell mass expansion.

Funder

National Key Research and Development Program of China

Chinese Academy of Medical Sciences

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00025.2021

Reference45 articles.

1. Metabolism and the Circadian Clock Converge