Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects-Reference-Cited by-同舟云学术

Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects

Published:2021-11-01 Issue:5 Volume:321 Page:E728-E736
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Adams Jon D.¹²,Egan Aoife M.¹,Laurenti Marcello C.¹,Schembri Wismayer Daniel¹,Bailey Kent R.³,Cobelli Claudio⁴,Dalla Man Chiara⁵^ORCID,Vella Adrian¹^ORCID

Affiliation:

1. Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota

2. Department of Health and Human Performance, College of Charleston, Charleston, South Carolina

3. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota

4. Department of Woman and Child’s Health, University of Padova, Padova, Italy

5. Department of Information Engineering, University of Padova, Padova, Italy

Abstract

In prediabetes, anthropometric characteristics as well as insulin action do not alter the hepatic response to glucagon. The postprandial suppression or lack of suppression of glucagon secretion is an important factor governing postprandial glucose tolerance independent of insulin secretion.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Mayo Clinic General Clinical Research Center

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00284.2021

Reference31 articles.

1. THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS

2. Impact of lack of suppression of glucagon on glucose tolerance in humans