Obesity protects against sepsis-induced and norepinephrine-induced white adipose tissue browning-Reference-Cited by-同舟云学术

Obesity protects against sepsis-induced and norepinephrine-induced white adipose tissue browning

Published:2021-09-01 Issue:3 Volume:321 Page:E433-E442
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Li Cheryl¹,Davis Xenia¹,Lahni Patrick¹,Stuck Joanna¹,Williamson Lauren¹,Kaplan Jennifer¹²^ORCID

Affiliation:

1. Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio

Abstract

White adipose tissue browning is detrimental in patients with burn injury and cancer. WAT browning occurs in nonobese mice and can be induced by β receptor norepinephrine infusion, but obese mice are resistant to sepsis-induced and norepinephrine-induced WAT browning. We propose that the lack of WAT browning and unchanged inflammatory cytokine response may contribute to the protection of obese mice from sepsis.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00380.2020

Reference45 articles.

1. The role of obesity in the immune response during sepsis

2. Varying Estimates of Sepsis Mortality Using Death Certificates and Administrative Codes — United States, 1999–2014