Separating insulin-mediated and non-insulin-mediated glucose uptake during and after aerobic exercise in type 1 diabetes

Author:

Nguyen Thanh-Tin P.1,Jacobs Peter G.2,Castle Jessica R.3,Wilson Leah M.3,Kuehl Kerry4,Branigan Deborah3,Gabo Virginia3,Guillot Florian3,Riddell Michael C.5,Haidar Ahmad6,El Youssef Joseph23ORCID

Affiliation:

1. School of Medicine, Oregon Health & Science University, Portland, Oregon

2. Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon

3. Harold Schnitzer Diabetes Health Center, Oregon Health & Science University, Portland, Oregon

4. Department of Sports Medicine, Oregon Health & Science University, Portland, Oregon

5. School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada

6. Institut de Recherches Cliniques de Montréal, Montreal, Quebec, Canada

Abstract

Separating insulin and non-insulin glucose uptake dynamically during exercise in type 1 diabetes has not been done before. We use a multistep process, including a previously described linear regression method, over three insulin infusion sessions, to perform this separation and can graph these components before, during, and after exercise for the first time.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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