17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice-Reference-Cited by-同舟云学术

17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice

Published:2024-03-01 Issue:3 Volume:326 Page:E226-E244
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Bubak Matthew P.¹^ORCID,Mann Shivani N.²,Borowik Agnieszka K.¹^ORCID,Pranay Atul¹,Batushansky Albert¹³,Vieira de Sousa Neto Ivo¹^ORCID,Mondal Samim A.¹^ORCID,Doidge Stephen M.¹,Davidyan Arik⁴^ORCID,Szczygiel Marcelina M.¹,Peelor Frederick F.¹,Rigsby Sandra¹,Broomfield Matle E.¹,Lacy Charles I.⁵,Rice Heather C.⁵,Stout Michael B.¹⁶^ORCID,Miller Benjamin F.¹⁶^ORCID

Affiliation:

1. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States

2. Department of Neuroscience, University of Arizona, Tucson, Arizona, United States

3. Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer-Sheba, Israel

4. Department of Biological Sciences, California State University, Sacramento, California, United States

5. Department of Biochemistry and Molecular Biology, Oklahoma Center for Geroscience and Healthy Brain Aging, Oklahoma City, Oklahoma, United States

6. Oklahoma City Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States

Abstract

Using a multiomics approach, we show that 17α-E2 alleviates HFD-induced metabolic detriments in skeletal muscle by altering bioactive lipid intermediates, inflammatory cytokines, and the abundance of proteins related to lipolysis and muscle contraction. The positive effects of 17α-E2 in skeletal muscle occur in both sexes but differ in their outcome.

Funder

U.S. Department of Veterans Affairs

Sao Paulo Research Foundation

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00215.2023

Reference70 articles.

1. Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

2. 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

3. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

4. 17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner

5. Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus);GeroScience;2024-08-06