Brown adipose tissue metabolism in women is dependent on ovarian status-Reference-Cited by-同舟云学术

Brown adipose tissue metabolism in women is dependent on ovarian status

Published:2024-05-01 Issue:5 Volume:326 Page:E588-E601
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Blondin Denis P.¹²^ORCID,Haman François³,Swibas Tracy M.⁴,Hogan-Lamarre Sophie²⁵,Dumont Lauralyne²⁵^ORCID,Guertin Jolan²⁵,Richard Gabriel²,Weissenburger Quentin²,Hildreth Kerry L.⁴^ORCID,Schauer Irene⁶⁷^ORCID,Panter Shelby⁸⁶,Wyland Liza⁶,Carpentier André C.⁹^ORCID,Miao Yubin¹⁰,Shi Jiayuan¹¹,Juarez-Colunga Elizabeth¹¹⁷,Kohrt Wendy M.⁴⁷,Melanson Edward L.⁴⁶⁷^ORCID

Affiliation:

1. Division of Neurology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada

2. Centre de Recherche du Centre Hospitalier, Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

3. School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada

4. Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

5. Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier, Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

6. Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

7. Eastern Colorado Veterans Affairs Geriatric Research, Education, and Clinical Center, Denver, Colorado, United States

8. Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

9. Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier, Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada

10. Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

11. Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Abstract

In rodents, loss of estrogen reduces brown adipose tissue (BAT) activity. Whether this is true in humans is not known. We found that BAT oxidative metabolism and glucose uptake were lower in postmenopausal compared to premenopausal women. In premenopausal women who underwent ovarian suppression to reduce circulating estrogen, BAT oxidative metabolism was reduced to postmenopausal levels. Thus the loss of ovarian function in women leads to a reduction in BAT metabolic activity independent of age.

Funder

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute on Aging

Eastern Colorado VA GHeriatric Research, Education, and Clinical Center

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00077.2024

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