Triacylglycerol lipases and metabolic control: implications for health and disease-Reference-Cited by-同舟云学术

Triacylglycerol lipases and metabolic control: implications for health and disease

Published:2010-08 Issue:2 Volume:299 Page:E162-E168
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Watt Matthew J.¹,Spriet Lawrence L.²

Affiliation:

1. Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia; and

2. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

Abstract

Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during physical activity. This review outlines the identification of the new TG lipase, adipose triglyceride lipase, the current understanding of how cellular TG lipases are regulated, and the implications for understanding the integrated control of TG lipolysis. Furthermore, this review outlines recent advances that propose a “revised” role for TG lipases in cellular function, metabolic homeostasis, and disease prevention.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://www.physiology.org/doi/pdf/10.1152/ajpendo.00698.2009

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