1. Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;
2. Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa, Tokyo, Japan;
3. Department of Laboratory Medicine and Pathobiology, Ted Rogers Centre for Heart Research TBEP/ University of Toronto, Ontario, Canada; and
4. Department of Physiology and Medicine, Institute of Medical Science, Banting and Best Diabetes Centre, Toronto, Ontario, Canada