Exploring the role of osteoglycin in type 2 diabetes: implications for insulin resistance and vascular pathophysiology-Reference-Cited by-同舟云学术

Exploring the role of osteoglycin in type 2 diabetes: implications for insulin resistance and vascular pathophysiology

Published:2023-11-01 Issue:5 Volume:325 Page:E649-E660
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

González-Salvatierra Sheila¹²³,García-Fontana Beatriz¹²⁴⁵,Martínez-Heredia Luis¹,Lacal Jesus⁶⁷,Andújar-Vera Francisco⁸⁹¹⁰,Sanabria-de la Torre Raquel¹¹¹,Moratalla-Aranda Enrique¹¹²,Lozano-Alonso Silvia¹¹³,García-Fontana Cristina¹²⁴,Muñoz-Torres Manuel¹²⁴¹⁴

Affiliation:

1. Biosanitary Research Institute of Granada (ibs.GRANADA), Granada, Spain

2. Endocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain

3. Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain

4. CIBER of Frailty and Healthy Aging (CIBERFES) Institute of Health Carlos III, Madrid, Spain

5. Department of Cell Biology, University of Granada, Granada, Spain

6. Laboratory of Functional Genetics of Rare Diseases, Department of Microbiology and Genetics, University of Salamanca (USAL), Salamanca, Spain

7. Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain

8. Bioinformatic Research Service, Biosanitary Research Institute of Granada (ibs.GRANADA), Granada, Spain

9. Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain

10. Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI Institute), Granada, Spain

11. Department of Biochemistry, Molecular Biology III and Immunology, University of Granada, Granada, Spain

12. Nuclear Medicine Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain

13. Angiology and Vascular Surgery Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain

14. Department of Medicine, University of Granada, Granada, Spain

Abstract

This study uncovers an increase of serum osteoglycin levels in patients with type 2 diabetes, which does not appear to be associated with the development of atherosclerosis, but rather with insulin resistance in this population. Overexpression of osteoglycin increased proliferation and upregulated the expression of autotaxin in vascular smooth muscle cells within calcified environments. Osteoglycin could be a biomarker of insulin resistance for type 2 diabetes and could be indirectly involved in the development of atherosclerosis.

Funder

MEC | Instituto de Salud Carlos III

Junta de Andalucía

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00320.2023

Reference45 articles.

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