Pituitary adenylate cyclase-activating polypeptide receptor activation in the hypothalamus recruits unique signaling pathways involved in energy homeostasis-Reference-Cited by-同舟云学术

Pituitary adenylate cyclase-activating polypeptide receptor activation in the hypothalamus recruits unique signaling pathways involved in energy homeostasis

Published:2022-03-01 Issue:3 Volume:322 Page:E199-E210
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Maunze Brian¹^ORCID,Bruckner Katherine Wood¹,Desai Nikhil Nilesh¹,Chen Christopher¹,Chen Fanghong¹,Baker David¹,Choi SuJean¹^ORCID

Affiliation:

1. Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin

Abstract

Endogenous PAC1 receptors, integral to VMN management of feeding behavior and body weight regulation, uniquely engage PKA, PKC, and receptor trafficking to mediate the hypothalamic ventromedial nuclei control of feeding and metabolism. PACAP appears to use different signaling mechanisms to regulate feeding behavior from its effects on metabolism.

Funder

HHS | NIH | NIDA | National Drug Abuse Treatment Clinical Trials Network

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00320.2021

Reference57 articles.

1. Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity

2. Role of Pituitary Adenylate Cyclase-Activating Polypeptide in the Pancreatic Endocrine System