Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging-Reference-Cited by-同舟云学术

Adipocyte-specific inactivation of NAMPT, a key NAD⁺ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging

Published:2024-07-01 Issue:1 Volume:327 Page:E81-E88
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Qi Nathan¹,Franczyk Michael P.²,Yamaguchi Shintaro²³,Kojima Daiki³^ORCID,Hayashi Kaori³,Satoh Akiko⁴⁵,Ogiso Noboru⁶,Kanda Takeshi⁷⁸,Sasaki Yo⁹,Finck Brian N.²^ORCID,DeBosch Brian J.¹⁰¹¹^ORCID,Yoshino Jun²³⁷⁸^ORCID

Affiliation:

1. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States

2. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, United States

3. Division of Endocrinology, Metabolism and Nephrology Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

4. Department of Integrative Physiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

5. Department of Integrative Physiology, National Center for Geriatrics and Gerontology, Obu, Japan

6. Laboratory of Experimental Animals, National Center for Geriatrics and Gerontology, Obu, Japan

7. Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Shimane University, Izumo, Japan

8. The Center for Integrated Kidney Research and Advance (IKRA), Faculty of Medicine, Shimane University, Izumo, Japan

9. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States

10. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States

11. Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States

Abstract

Defective NAD+ metabolism is associated with aging and age-associated metabolic diseases. In the present study, we provided in-depth metabolic assessments in female mice with adipocyte-specific inactivation of a key NAD+ biosynthetic enzyme NAMPT and revealed an unexpected role of adipose tissue NAMPT-NAD+-PPAR-γ axis in maintaining functional integrity and quantity of adipose tissue and whole body metabolic health during the aging process.

Funder

Astellas Pharma

HHS | NIH | National Cancer Institute

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00313.2023

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