Lauric acid impairs insulin-induced Akt phosphorylation by upregulating <i>SELENOP</i> expression via HNF4α induction-Reference-Cited by-同舟云学术

Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4α induction

Published:2022-06-01 Issue:6 Volume:322 Page:E556-E568
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Kamoshita Kyoko¹,Tsugane Hirohiko²,Ishii Kiyo-Aki¹³^ORCID,Takayama Hiroaki¹⁴⁵,Yao Xingyu¹,Abuduwaili Halimulati¹,Tanida Ryota¹,Taniguchi Yasumasa¹,Oo Hein Ko¹,Gafiyatullina Guzel¹,Kaneko Shuichi⁴,Matsugo Seiichi²,Takamura Toshinari¹^ORCID

Affiliation:

1. Department of Endocrinology and Metabolism, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

2. Faculty of Natural System, Institute of Science and Engineering, Kanazawa University, Kanazawa, Japan

3. Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

4. Department of System Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

5. Life Sciences Division, Engineering and Technology Department, Kanazawa University, Kanazawa, Japan

Abstract

Lauric acid induces hepatic insulin resistance by upregulating Selenop. These findings caution the metabolic risk of excessive lauric acid intake, especially in people with hepatic insulin resistance associated with type 2 diabetes.

Funder

MEXT | Japan Society for the Promotion of Science

Takeda Science Foundation

Yamaguchi Endocrine Research Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00163.2021

Reference39 articles.

1. SELENOPROTEIN P: An Extracellular Protein with Unique Physical Characteristics and a Role in Selenium Homeostasis