Altered adipokines in obese adolescents: a cross-sectional and longitudinal analysis across the spectrum of glycemia

Author:

Wolf Risa M.123ORCID,Jaffe Andrew E.45678,Rodriguez Susana23,Lei Xia23910,Sarver Dylan C.23,Straub Alexander T.411,Wong G. William23,Magge Sheela N.1

Affiliation:

1. Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland

2. Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland

3. Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland

4. Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland

5. Department of Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland

6. Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland

7. Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland

8. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

9. Department of Biochemistry, Oklahoma State University, Stillwater, Oklahoma

10. Department of Molecular Biology, Oklahoma State University, Stillwater, Oklahoma

11. University of Maryland, College Park, Maryland

Abstract

Leptin is higher in obese adolescents and FGF21 is higher in obese hyperglycemic adolescents. The novel adipokine CTRP1 is higher in obese hyperglycemic adolescents, whereas CTRP9 was unchanged in this adolescent cohort.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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