Stimulation of G<sub>s</sub> signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice-Reference-Cited by-同舟云学术

Stimulation of G_s signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice

Published:2022-05-01 Issue:5 Volume:322 Page:E436-E445
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Matsumura Shigenobu¹²^ORCID,Miyakita Motoki¹,Miyamori Haruka¹,Kyo Satomi³,Shima Daisuke⁴,Yokokawa Takumi¹,Ishikawa Fuka¹,Sasaki Tsutomu⁵,Jinno Tomoki¹,Tanaka Jin¹,Goto Tsuyoshi¹,Momma Keiko³,Ishihara Kengo⁴,Berdeaux Rebecca⁶^ORCID,Inoue Kazuo¹^ORCID

Affiliation:

1. Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

2. Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan

3. Department of Food and Nutrition, Kyoto Women’s University, Kyoto, Japan

4. Department of Food Sciences and Human Nutrition, Faculty of Agriculture, Ryukoku University, Shiga, Japan

5. Department of Neurology, Graduate School of Medicine, Osaka University, Osaka, Japan

6. Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas

Abstract

We report that Gs signaling in melanocortin 4 receptor (MC4R)-expressing cells regulates energy expenditure, appetite, and locomotor activity. These findings shed light on the mechanism underlying the regulation of energy metabolism and locomotor activity by MC4R/cAMP signaling.

Funder

MEXT | Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00439.2021

Reference42 articles.

1. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

2. The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics