Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers

Author:

Haddad-Tóvolli Roberta12ORCID,Morari Joseane1,Barbizan Roberta1,Bóbbo Vanessa C.1,Carraro Rodrigo S.13,Solon Carina1,Dragano Nathalia R.1,Torsoni Márcio A.4ORCID,Araujo Eliana P.15,Velloso Licio A.1ORCID

Affiliation:

1. Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas, Campinas, Brazil

2. Neuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

3. Center for Anatomy Studies, University San Francisco (USF), Bragança Paulista, Brazil

4. Laboratory of Metabolic Disorders, Faculty of Applied Sciences, State University of Campinas, Campinas, Limeira, Brazil

5. School of Nursing, University of Campinas, Campinas, Brazil

Abstract

Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME–BBB, accompanied by changes in the expression of transcripts encoding for endothelial and tanycytic proteins, as well as of hypothalamic neuropeptides. Breastfeeding in lean dams was sufficient to protect the offspring from ME–BBB disruption, providing a preventive strategy of nutritional intervention during early life.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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