NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC-matched ICR mice-Reference-Cited by-同舟云学术

NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC-matched ICR mice

Published:2023-10-01 Issue:4 Volume:325 Page:E336-E345
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Batdorf Heidi M.¹,Lawes Luz de Luna¹,Richardson Jeremy T.¹,Burk David H.²,Dupuy Samuel D.³,Karlstad Michael D.³,Noland Robert C.⁴^ORCID,Burke Susan J.⁵,Collier J. Jason¹

Affiliation:

1. Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

2. Cell Biology and Bioimaging Core Facility, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

3. Department of Surgery, Graduate School of Medicine, University of Tennessee Health Science Center, Knoxville, Tennessee, United States

4. Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

5. Laboratory of Immunogenetics, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

Abstract

Nonobese diabetic (NOD) mice have more proinsulin in circulation and STAT1 protein in islets compared with the major histocompatibility complex (MHC)-matched ICR line. NOD mice also display greater expression of cytokines and chemokines in pancreatic islets consistent with immune cell infiltration before hyperglycemia when compared with age-matched ICR mice. Thus, ICR mice represent an excellent control for autoimmunity and inflammation studies using the NOD line of mice.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00033.2023

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