Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS-Reference-Cited by-同舟云学术

Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS

Published:2023-10-01 Issue:4 Volume:325 Page:E346-E362
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Zuo Wenting¹^ORCID,Liu Xiangfei²,Chen Jianhuai³,Zuo Wenren⁴,Yin Yanyun¹,Nie Xiaowei¹,Tang Peipei¹,Huang Yunke⁵,Yu Qian⁶,Hu Qiaoyun⁷,Zhou Jie⁸,Tan Yong¹,Huang Xi²,Ren Qingling⁹^ORCID

Affiliation:

1. Department of Reproductive Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China

2. State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China

3. Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China

4. Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China

5. Department of Gynaecology, Women’s Hospital School of Zhejiang University, Hangzhou, People’s Republic of China

6. Department of Science and Technology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China

7. Singleron Biotechnologies, Nanjing, People’s Republic of China

8. Department of Traditional Chinese Medicine, The First People’s Hospital of Nantong, Nantong, People’s Republic of China

9. Department of Gynaecology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China

Abstract

In this study, we mapped the landscape of polycystic ovary syndrome (PCOS) ovary with rat model induced by letrozole and provided a novel insight into the molecular mechanism of PCOS accompanied by chronic unpredicted mild stress (CUMS) at single-cell transcriptomic level. These observations highlight the importance of inflammation in the pathogenesis of PCOS, which might also be the bridge between PCOS and psychological diseases.

Funder

special project of innovation and development fund of jiangsu province hospital of chinese medicine

jiangsu province graduate research and practice innovation program project-school assisted general project

center for innovation in obstetrics and reproduction of jiangsu province hospital of chinese medicine

national natural science foundation of china

project of jiangsu province bureau

hospital-level project of jiangsu province hospital of chinese medicine

jiangsu traditional chinese medicine science of technology development plan project

excellent young doctor training program of jiangsu province hospital of chinese medicine

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00165.2023

Reference82 articles.

1. Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile

2. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

3. The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator

4. A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility

5. Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus)

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