<i>TAF1</i> is needed for the proliferation and maturation of thyroid follicle cells via Notch signaling-Reference-Cited by-同舟云学术

TAF1 is needed for the proliferation and maturation of thyroid follicle cells via Notch signaling

Published:2024-06-01 Issue:6 Volume:326 Page:E832-E841
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Zhang Caoxu¹,Yang Liu¹,Zhang Haiyang¹,Wu Fengyao¹,Zhang Yue¹,Zhang Kaiwen¹,Wu Chenyang¹,Li Rui¹,Dong Mei¹,Zhao Shuangxia¹,Song Huaidong¹^ORCID

Affiliation:

1. Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China

Abstract

In our study, we obtained a novel zebrafish line with thyroid dysgenesis (TD) and identified the candidate pathogenetic mutation TATA-box binding protein associated Factor 1 ( taf1). Further researches revealed that taf1 was required for thyroid follicular cells by binding to the NOTCH1 promoter region. Our findings revealed a novel role of TAF1 in thyroid morphogenesis.

Funder

Innovative Research Team of High-level Local University in Shanghai

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00403.2023

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