Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability-Reference-Cited by-同舟云学术

Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability

Published:2022-09-01 Issue:3 Volume:323 Page:E307-E318
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Frøbert Anne Mette¹^ORCID,Brohus Malene¹^ORCID,Roesen Tinna S.¹,Kindberg Jonas²³^ORCID,Fröbert Ole⁴⁵⁶⁷^ORCID,Conover Cheryl A.⁸^ORCID,Overgaard Michael T.¹^ORCID

Affiliation:

1. Department of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark

2. Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden

3. Norwegian Institute for Nature Research, Trondheim, Norway

4. Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden

5. Department of Clinical Medicine, Aarhus University Health, Aarhus, Denmark

6. Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark

7. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

8. Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota

Abstract

Brown bears shift from circulating ternary IGF/IGFBP/ALS complexes in the active state to binary IGF/IGFBP complexes during hibernation, indicating increased tissue IGF-bioactivity. Furthermore, brown bears use a splice variant of IGF-2, suggesting increased bone-specific targeting of IGF anabolic signaling.

Funder

Lundbeckfonden

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00429.2021

Reference35 articles.

1. Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators?

2. Hibernation in Black Bears: Independence of Metabolic Suppression from Body Temperature

3. Denning behaviour of Scandinavian brown bears Ursus arctos

4. Vitamin D Status and Bone and Connective Tissue Turnover in Brown Bears (Ursus arctos) during Hibernation and the Active State

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