Mechanisms of spinophilin-dependent pancreas dysregulation in obesity-Reference-Cited by-同舟云学术

Mechanisms of spinophilin-dependent pancreas dysregulation in obesity

Published:2024-08-01 Issue:2 Volume:327 Page:E155-E171
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Stickel Kaitlyn C.¹,Shah Nikhil R.²,Claeboe Emily T.³,Orr Kara S.⁴^ORCID,Mosley Amber L.⁴⁵⁶⁷,Doud Emma H.⁵⁶^ORCID,Belecky-Adams Teri L.¹,Baucum Anthony J.¹³⁴⁸^ORCID

Affiliation:

1. Department of Biology, Indiana University-Indianapolis, Indianapolis, Indiana, United States

2. Medical Neurosciences and Medical Scientist Training Program, Indiana University School of Medicine, Indianapolis, Indiana, United States

3. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States

4. Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, United States

5. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States

6. Center for Proteome Analysis, Indiana University School of Medicine, Indianapolis, Indiana, United States

7. Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States

8. Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States

Abstract

To our knowledge, these data are the first to demonstrate that obesity impacts spinophilin protein interactions in the pancreas and identify spinophilin specifically in pancreatic β cells as a modulator of whole body glucose tolerance.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | NIDA | National Drug Abuse Treatment Clinical Trials Network

HHS | NIH | National Cancer Institute

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Eye Institute

Indiana University-Purdue University Indianapolis

School of Medicine, Indiana University

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00099.2023

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