Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer-Reference-Cited by-同舟云学术

Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer

Published:2023-02-01 Issue:2 Volume:324 Page:E144-E153
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Eljalby Mahmoud¹²,Huang Xiaojing¹³,Becher Tobias¹⁴⁵,Wibmer Andreas G.⁶,Jiang Caroline S.⁷,Vaughan Roger⁷⁸,Schöder Heiko⁶,Cohen Paul¹^ORCID

Affiliation:

1. Laboratory of Molecular Metabolism, The Rockefeller University, New York, New York

2. Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas

3. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York

4. DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Mannheim, Germany

5. First Department of Medicine (Division of Cardiology), University Medical Center Mannheim, Mannheim, Germany

6. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York

7. Center for Clinical and Translational Science, The Rockefeller University, New York City, New York

8. Graduate School of Medical Sciences, Weill Cornell Medicine, New York City, New York

Abstract

This study finds that brown fat is not linked to cancer-associated cachexia. Moreover, this work shows that brown fat does not worsen overall survival in patients with cachexia.

Funder

Rockefeller University

Sinsheimer Foundation

American Diabetes Association

HHS | NIH | National Cancer Institute

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00187.2022