Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD-Reference-Cited by-同舟云学术

Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD

Published:2022-09-01 Issue:3 Volume:323 Page:E187-E206
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Manjarín Rodrigo¹^ORCID,Dillard Kayla²,Coffin Morgan¹,Hernandez Gabriella V.¹,Smith Victoria A.¹,Noland-Lidell Trista¹,Gehani Tanvi R.³,Smart Hayden J.¹,Wheeler Kevin⁴,Sprayberry Kimberly A.¹,Edwards Mark S.¹,Fanter Rob K.⁵⁶,Glanz Hunter⁷,Immoos Chad⁸,Santiago-Rodriguez Tasha M.⁹,Blank Jason M.⁴,Burrin Douglas G.¹⁰^ORCID,Piccolo Brian D.¹¹¹²^ORCID,Abo-Ismail Mohammed¹,La Frano Michael R.²¹³^ORCID,Maj Magdalena⁴¹⁴

Affiliation:

1. Department of Animal Science, California Polytechnic State University, San Luis Obispo, California

2. Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California

3. Department of Biomedical Engineering, California Polytechnic State University, San Luis Obispo, California

4. Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, California

5. College of Agriculture, Food and Environmental Sciences, California Polytechnic State University, San Luis Obispo, California

6. Center for Health Research, California Polytechnic State University, San Luis Obispo, California

7. Department of Statistics, California Polytechnic State University, San Luis Obispo, California

8. Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, California

9. Diversigen, Inc., Houston, Texas

10. USDA-ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

11. USDA-ARS Arkansas Children’s Nutrition Center, Little Rock, Arkansas

12. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas

13. Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, California

14. Center for Applications in Biotechnology, California Polytechnic State University, San Luis Obispo, California

Abstract

Bile acid homeostasis and signaling is disrupted in NAFLD and may play a central role in the development of the disease. However, there are no studies addressing the impact of diet on bile acid metabolism in patients with NAFLD. In juvenile Iberian pigs, we show that fatty acid composition in high-fat high-fructose diets affects BA levels in liver, plasma, and colon but these changes were not associated with the severity of the disease.

Funder

Agriculture Research Institute, California State University

USDA, Agricultural Research Service

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00052.2022

Reference83 articles.

1. Epidemiology of Pediatric Nonalcoholic Fatty Liver Disease