Radiation exposure from long-lived beta emitters in clinical investigation

Author:

Landau B. R.1,Shreeve W. W.1

Affiliation:

1. Department of Medicine, Case Western Reserve University School ofMedicine, Cleveland, Ohio 44106.

Abstract

Potential hazards restrict the use of 14C in clinical investigation. Nevertheless, 14C, in readily metabolized compounds, continues to be administered and in relatively large doses. The compounds are converted to intermediates and products with longer half-lives than their half-lives. These longer biological half-lives have not always been taken into account, although calculations of radiation exposure can be markedly altered by their inclusion. The minimum dose of 14C needed to accomplish a study must also be considered, and benefits relative to risks in the administration must be assessed in terms of the kind and total number of subjects required. Similar considerations apply to the administration of 3H-labeled compounds. Furthermore, in assessing risks, the limited information available on the localization and concentration of the isotopes in the body should be taken into account. There are also concerns with regard to administrations in growth situations and to an individual on multiple occasions. Within those constraints, 14C and 3H can be given with relative safety.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The measurement of tissue protein turnover;Baillière's Clinical Endocrinology and Metabolism;1996-10

2. Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state.;Journal of Clinical Investigation;1995-01-01

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3