Renal ischemia/reperfusion induces prominent progressive kidney disease in diabetic mice-Reference-Cited by-同舟云学术

Renal ischemia/reperfusion induces prominent progressive kidney disease in diabetic mice

Published:2024-09-01 Issue:3 Volume:327 Page:E302-E312
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

de Ponte Mariana Charleaux¹,Cardoso Vanessa Gerolde¹,Costa-Pessoa Juliana Martins da¹^ORCID,Lopes-Gonçalves Guilherme¹,Pereira Beatriz Maria Veloso²,Thieme Karina²^ORCID,Oliveira-Souza Maria¹^ORCID

Affiliation:

1. Laboratory of Renal Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

2. Laboratory of Cellular and Molecular Bases of Renal Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

Abstract

This study demonstrated that early diabetes potentiates progressive kidney disease after ischemia/reperfusion (IR)-induced acute kidney injury, mainly by exacerbating pro-inflammatory and sustaining fibrotic responses and altering renal glucose metabolism. Thus, these findings will contribute to the therapeutic support of patients with type 1 diabetes with eventual renal IR intervention in clinical practice.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00237.2023

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