Roux-en-Y gastric bypass restores islet function and morphology independent of body weight in ZDF rats-Reference-Cited by-同舟云学术

Roux-en-Y gastric bypass restores islet function and morphology independent of body weight in ZDF rats

Published:2021-02-01 Issue:2 Volume:320 Page:E392-E398
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Mosinski J. David¹²,Aminian Ali³,Axelrod Christopher L.⁴⁵⁶^ORCID,Batayyah Esam³,Romero-Talamas Hector³,Daigle Christopher³,Mulya Anny¹⁷,Scelsi Amanda¹,Schauer Philip R.³⁶⁷,Brethauer Stacy A.³⁷,Kirwan John P.¹⁵⁶⁷^ORCID

Affiliation:

1. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio

2. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio

3. Bariatric Metabolic Institute, Cleveland Clinic, Cleveland, Ohio

4. Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, Louisiana

5. Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana

6. Bariatric and Metabolic Institute, Pennington Biomedical Research Center, Baton Rouge, Louisiana

7. Metabolic Translational Research Center, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio

Abstract

The onset and progression of type 2 diabetes (T2D) results from failure to secrete sufficient amounts of insulin to overcome peripheral insulin resistance. Here, we demonstrate that Roux-en-Y gastric bypass (RYGB) restores islet function and morphology compared to sham and pair-fed controls in ZDF rats. The improvements in islet function were largely attributable to enhanced insulin content and secretory function in response to glucose stimulation.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

Cleveland Clinic

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00467.2020

Reference29 articles.

1. Bariatric Surgery vs Lifestyle Intervention for Diabetes Treatment: 5-Year Outcomes From a Randomized Trial