Estrogen-Wnt signaling cascade regulates expression of hepatic fibroblast growth factor 21-Reference-Cited by-同舟云学术

Estrogen-Wnt signaling cascade regulates expression of hepatic fibroblast growth factor 21

Published:2021-08-01 Issue:2 Volume:321 Page:E292-E304
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Badakhshi Yasaman¹²³,Shao Weijuan¹²³,Liu Dinghui¹⁴,Tian Lili²³,Pang Juan¹⁵,Gu Jianqiu²⁶,Hu Jim⁷,Jin Tianru¹²³^ORCID

Affiliation:

1. Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada

2. Divison of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada

3. Banting and Best Diabetes Centre, Faculty of Medicine, University of Toronto, Toronto, Canada

4. Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China

5. Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China

6. Departmemt of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, People’s Republic of China

7. Hospital for Sick Children, Toronto, Ontario, Canada

Abstract

FGF21 is mainly produced in the liver. Therapeutic effect of FGF21 analogues has been demonstrated in clinical trials on reducing hyperlipidemia. We show here that Fgf21 transcription is positively regulated by Wnt pathway effector β-cat/TCF. Importantly, hepatic β-cat/TCF activity can be regulated by the female hormone estradiol, involving GPER. The investigation enriched our understanding on hepatic FGF21 hormone production, and expanded our view on metabolic functions of the Wnt pathway in the liver.

Funder

Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00638.2020

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